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A BIT ABOUT SARS-COV-2

What makes it so infectious?

  • SARS-CoV-2 cell adhesion depends on the binding of the viral Spike protein’s S1 subunit to the ACE2 Cell receptor.

  • NRP1 NRP2 (Neuropilin) provide additional adhesion sites that improve viral entry and binding

  • TMPRSS2 (transmembrane serine protease 2). A nuance of this virus is the cleavage that happens  at the S1/S2 junction. This mediates membrane fusion and cellular entry

  • The S1/S2 cleavage subunits are not present in SARS-CoV-1 making SARS-CoV-2 a more potent binding virus.

INCREASED NRP1 role in WT COVID Infection
Infection of Human cells by lentiviral particles pseudo-typed with COVID-19 S protein
About COVID-19: About
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