IMMUNE EVASION PROPERTIES OF COVID-19

Focused on Understanding

Mechanisms of COVID Evasion

• Viral avoidance -  COVID improves its chances of successful replication by packaging dsRNA in double membrane vesicles.

• Cells near the site of initial COVID-19 infection fail to receive IFN signals due to viral interference. Viral spread benefits.

• Inhibition of STAT1 phosphorylation mediated by virus. Effectively blocks interferon response in dendritic cells and macrogphages