top of page

INNATE/ADAPTIVE RESPONSE TO COVID-19

This section will focus on the innate response vs the adaptive response our body mounts in response to COVID.

Scientist in the Lab

Nuance

A higher concentration of innate immune response has been seen to be elucidated by COVID-19.

​

After sequencing Bronchoalveolar Lavage Fluid cells from the esophagi of COVID patients demonstrate higher levels of transcription of genes for cytokines and interferon stimulated genes

​

Neutrophils, Eosinophiles, Macrgophages, Dendritic cells account for the release of innate Cytokines. 

​

Generally

In pediatric patients vs older, The innate response is more tame in the younger group

Acute responses, overburdening of the body by cytokines (IL-1, IL-6, IL-8, CXCL-10) have resulted in the most severe COVID cases.

Embryonic Stem Cells

Humoral and Cellular Response

-N & S specific antibody release by B cells target virus

- Viral antigen presentation causes cellular response and activation of CD8+ cytotoxic T cells and CD4+ T helper cells.


​

​

T cell recruitment - effectiveness of the adaptive pathway determines the bodies ability to ward off disease severity.

Cytokine Storm (IL-6, IL-10, and TNFα) and significantly reduced CD4+ and CD8+ T cells recruitment allows COVID to overwhelm body.

​

​

Overbearing Cytokine production from dysregulated immune response causes hyperinflammation. Marginalizes the effectiveness of antiviral agents alone as a treatment because hyperinflammation from own body's cytokine production persists.

Innate/Adaptive Response: Research
bottom of page